What BREZTRI is for

What is the approved use for BREZTRI?

BREZTRI is a prescription medicine used long term to treat chronic obstructive pulmonary disease (COPD). COPD is a chronic lung disease that includes chronic bronchitis, emphysema, or both. BREZTRI is used long term as 2 inhalations 2 times each day (2 puffs in the morning and 2 puffs in the evening) to improve symptoms of COPD for better breathing* and to reduce the number of flare-ups (the worsening of your COPD symptoms for several days). BREZTRI is not used to relieve sudden breathing problems and won't replace a rescue inhaler. BREZTRI is not for the treatment of asthma.

*Results may vary

What are COPD flare-ups?

A COPD flare-up—also known as an exacerbation—is a sudden worsening of your COPD symptoms that result in additional treatment. If your COPD symptoms have been bad enough that you’ve had to get extra medical attention—such as being prescribed steroids or antibiotics—you’ve probably experienced a moderate COPD flare-up. If you’ve had to seek emergency care or have been hospitalized because of your COPD, you’ve probably experienced a severe COPD flare-up. That’s important to know because COPD flare-ups may cause permanent lung damage, but knowing the signs and symptoms could allow you to identify them—and then help prevent them.

Who should not take BREZTRI?

BREZTRI is not used to relieve sudden breathing problems and will not replace a rescue inhaler. It is not for the treatment of asthma. Do not use BREZTRI if you are allergic to budesonide, glycopyrrolate, formoterol, or any of the ingredients in BREZTRI.

How BREZTRI works

How can BREZTRI help me?

BREZTRI AEROSPHERE is a medicine used long term to treat chronic obstructive pulmonary disease (COPD), including chronic bronchitis, emphysema, or both, for better breathing^† and fewer flare-ups. BREZTRI is the first and only FDA-approved COPD medicine proven to reduce COPD flare-ups by 52%^‡. BREZTRI AEROSPHERE is used long term as 2 inhalations 2 times each day (2 puffs in the morning and 2 puffs in the evening).

^†Results may vary

^‡In a lung function study in patients with moderate to very severe COPD, with a majority having no flare-ups in the last 12 months. Flare-ups were reduced by 52% vs a dual bronchodilator—the combination of two medicines, an anticholinergic known as a long-acting muscarinic antagonist (LAMA) and a long-acting beta₂-adrenergic agonist (LABA).

What are the most common side effects of BREZTRI?

The most common side effects include: upper respiratory tract infection, pneumonia, hoarseness, back pain, thrush in your mouth and throat, flu, muscle spasms, urinary tract infection, cough, inflammation of the sinuses, and diarrhea. These are not all the possible side effects of BREZTRI. Ask your healthcare provider or pharmacist for more information. For full safety information, please click here.

How can I keep track of my doses?

There are several things you can do to help stay on track with your treatment:

• Piggyback your routine by taking your medicine while doing another activity you do twice a day, such as brushing your teeth or taking your dog for a walk.
• If friends or family members have asked how they can help, ask them to text or call you in the morning and evening to remind you.
• Put colorful sticky notes in places you’ll see them to remind you.
• Set a reminder alarm on your phone or computer.

What do I do if I think I’m having an allergic reaction to BREZTRI?

If you think you’re having an allergic reaction to BREZTRI—symptoms such as rash, hives, breathing problems, or swelling of the face, mouth, and tongue—call your doctor or get medical care immediately.

You may report side effects related to AstraZeneca products by clicking here.

What should I tell my doctor before using BREZTRI?

Before using BREZTRI AEROSPHERE, tell your healthcare provider about all of your medical conditions, including if you:

• have heart problems.
• have high blood pressure.
• have seizures.
• have thyroid problems.
• have diabetes.
• have liver problems.
• have kidney problems.
• have weak bones (osteoporosis).
• have an immune system problem.
• have eye problems such as glaucoma or cataracts. BREZTRI AEROSPHERE may make your glaucoma worse.
• have prostate or bladder problems, or problems passing urine. BREZTRI AEROSPHERE may make these problems worse.
• have any type of viral, bacterial, parasitic, or fungal infection.
• are exposed to chickenpox or measles.
• are pregnant or plan to become pregnant. It is not known if BREZTRI AEROSPHERE may harm your unborn baby.
• are breastfeeding. It is not known if the medicines in BREZTRI AEROSPHERE pass into your breast milk and if they can harm your baby. You and your healthcare provider should decide if you will take BREZTRI AEROSPHERE while breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. BREZTRI AEROSPHERE and certain other medicines may interact with each other. This may cause serious side effects.

Especially tell your healthcare provider if you take:

• anticholinergics (including tiotropium, ipratropium, aclidinium, and umeclidinium)
• other LABAs (including salmeterol, formoterol fumarate, arformoterol tartrate, vilanterol, olodaterol, and indacaterol)
• atropine
• antifungal or anti-HIV medicines

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist each time you get a new medicine.

Saving with BREZTRI

Are there savings offers for BREZTRI?

Yes. You may be eligible to pay as little as $0 on your prescription for BREZTRI for up to one year with BREZTRI Zero Pay. To find out if you qualify for savings, read the Eligibility Requirements.

How can I get help with insurance questions?

If you have questions regarding BREZTRI and your insurance, call the BREZTRI Information Center at 1-855-4-BREZTRI (Monday–Friday 8 AM–8 PM ET, excluding holidays). For more personalized information, contact your insurance company.

Your BREZTRI inhaler

How do I store my BREZTRI inhaler?

Store BREZTRI at room temperature between 68°F and 77°F (20°C and 25°C). Keep in a dry place away from heat and sunlight. Store BREZTRI in the unopened foil pouch and only open when ready for use. Safely throw BREZTRI away in the trash 3 months after you open the foil pouch or when the counter reads "0," whichever comes first. Learn more about your BREZTRI inhaler with these instructions for use.

Keep BREZTRI and all medicines out of the reach of children.

How do I administer BREZTRI?

For oral inhalation only. Use BREZTRI exactly as your healthcare provider tells you to. Start by priming your inhaler before using it for the first time. Remove the cap from the mouthpiece, hold it upright, facing away from you, and shake well. Push the canister all the way down until it stops moving in the actuator, to release a puff of medicine from the mouthpiece. You may hear a soft click from the dose indicator as it counts down. Repeat this process three times more.

To use the inhaler, take the cap off and shake the primed inhaler. Exhale as much as you reasonably can through your mouth, then close your lips around the mouthpiece and tilt your head back, keeping your tongue below the mouthpiece. Inhale deeply and slowly while pressing down on the canister until it stops moving. You should feel a puff of medicine. Remove the inhaler while holding your breath for as long as you comfortably can, up to 10 seconds, before breathing out gently. Repeat this process once more and replace the cap. You should be taking 2 puffs, 2 times a day. After your second puff, rinse your mouth with water to remove any excess medicine, making sure you don’t swallow the water.

For a more in-depth look at your inhaler and how to use it, please read these instructions for use.

How do I know I gave myself the full dose of medicine?

When you press down on the canister until it stops moving, you should feel a puff of medicine in your mouth. You may also hear a soft click from the dose indicator as it counts down.

How can I get help with using my BREZTRI inhaler?

For a more in-depth look at your inhaler and how to use it, please read these instructions for use. If you have additional questions, please reach out to your doctor.

Can I travel with my BREZTRI inhaler?

Yes, you can travel with your BREZTRI inhaler, but you will need to make sure it is kept in a dry place away from heat and sunlight.

What should I do if my BREZTRI inhaler looks damaged?

If your BREZTRI inhaler looks damaged, do not use it. Call your doctor immediately.

Patient Support

How can I learn more about available patient support?

The BREZTRI Support Experience is a full patient support program designed to help you feel empowered on your COPD journey. As a member of this one-of-a-kind community, you’ll receive educational information about managing your COPD, monthly newsletters, information about BREZTRI Zero Pay^§, and more, all while being surrounded by people who can relate to living with COPD. Learn more about everything the BREZTRI Support Experience offers by clicking here.

^§For eligible commercially insured patients only. Subject to applicable insurance plan’s eligibility rules and requirements; restrictions may apply.