BREZTRI AEROSPHERE is a medicine used long term to treat chronic obstructive pulmonary disease (COPD), including chronic bronchitis, emphysema, or both, for better breathing and fewer flare-ups.

BREZTRI is not used to relieve sudden breathing problems and will not replace a rescue inhaler. BREZTRI is not for the treatment of asthma. See more.

Possible Side Effects

TALK TO YOUR DOCTOR TO LEARN MORE ABOUT THEM

BREZTRI AEROSPHERE can cause serious side effects, including:

  • Fungal infection in your mouth or throat (thrush). Rinse your mouth with water without swallowing after using BREZTRI AEROSPHERE to help reduce your chance of getting thrush.
  • Pneumonia. People with COPD have a higher chance of getting pneumonia. BREZTRI AEROSPHERE may increase your chance of getting pneumonia. Call your healthcare provider if you notice any of the following symptoms:
    • increase in mucus (sputum) production
    • change in mucus color
    • fever
    • chills
    • increased cough
    • increased breathing problems
  • Weakened immune system and increased chance of getting infections (immunosuppression).
  • Reduced adrenal function (adrenal insufficiency). Adrenal insufficiency is a condition where the adrenal glands do not make enough steroid hormones. This can happen when you stop taking oral corticosteroid medicines (such as prednisone) and start taking a medicine containing an ICS (such as BREZTRI AEROSPHERE). During this transition period, when your body is under stress from fever, trauma (such as a car accident), infection, surgery, or worse COPD symptoms, adrenal insufficiency can get worse and may cause death.
    Symptoms of adrenal insufficiency include:
    • feeling tired
    • lack of energy
    • weakness
    • nausea and vomiting
    • low blood pressure (hypotension)
  • Sudden breathing problems immediately after inhaling your medicine. If you have sudden breathing problems immediately after inhaling your medicine, stop taking BREZTRI AEROSPHERE and call your healthcare provider right away.
  • Serious allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of a serious allergic reaction:
    • rash
    • hives
    • swelling of your face, mouth, and tongue
    • breathing problems
  • Effects on your heart.
    • increased blood pressure
    • a fast or irregular heartbeat
    • chest pain
  • Effects on your nervous system.
    • tremor
    • nervousness
  • Bone thinning or weakness (osteoporosis).
  • New or worsened eye problems including acute narrow-angle glaucoma and cataracts. Acute narrow-angle glaucoma can cause permanent loss of vision if not treated. Symptoms of acute narrow-angle glaucoma may include:
    • eye pain or discomfort
    • nausea or vomiting
    • blurred vision
    • seeing halos or bright colors around lights
    • red eyes
    If you have these symptoms, call your healthcare provider right away before taking another dose.
  • Urinary retention. People who take BREZTRI AEROSPHERE may develop new or worsening urinary retention. Symptoms of urinary retention may include:
    • difficulty urinating
    • urinating frequently
    • painful urination
    • urination in a weak stream or drips
    If you have these symptoms of urinary retention, stop taking BREZTRI AEROSPHERE and call your healthcare provider right away before taking another dose.
  • Changes in laboratory blood values, including high levels of blood sugar (hyperglycemia) and low levels of potassium (hypokalemia). Low levels of potassium may cause symptoms of muscle spasm, muscle weakness, or abnormal heart rhythm.

Common side effects of BREZTRI AEROSPHERE include

    • upper respiratory tract infection
    • pneumonia
    • back pain
    • thrush in your mouth and throat. Rinse your mouth with water without swallowing after use to help prevent this.
    • joint pain
    • flu
    • headache
    • high blood sugar levels
    • muscle spasms
    • cough
    • inflammation of the sinuses
    • diarrhea
    • hoarseness
    • painful and frequent urination (signs of a urinary tract infection)
    • nausea
    • difficulty sleeping
    • feeling anxious
    • awareness of your heart beating (palpitations)

Tell your healthcare provider about any side effect that bothers you or that does not go away.

These are not all the possible side effects of BREZTRI AEROSPHERE. Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice about side effects.

Please read Important Safety Information, Prescribing Information, Patient Information, and discuss with your doctor.

You may report side effects related to AstraZeneca products by clicking here.

See the BREZTRI Prescribing Information here

Frequently Asked Questions

What is the approved use for BREZTRI?

BREZTRI is a prescription medicine used long term to treat chronic obstructive pulmonary disease (COPD). COPD is a chronic lung disease...

What are COPD flare-ups?

A COPD flare-up—also known as an exacerbation—is a sudden worsening of your COPD symptoms that result in additional treatment. If your...

Are there savings offers for BREZTRI?

Yes. You may be eligible to pay as little as $0 on your prescription for BREZTRI for up to one year with BREZTRI Zero Pay. To find out if you qualify for...

How do I store my BREZTRI inhaler?

Store BREZTRI at room temperature between 68°F and 77°F (20°C and 25°C). Keep in a dry place away from heat and sunlight. Store BREZTRI in...

Stay up-to-date with BREZTRI, get COPD tips, and more.

APPROVED USE

BREZTRI AEROSPHERE is a medicine used long term to treat chronic obstructive pulmonary disease (COPD), including chronic bronchitis, emphysema, or both, for better breathing and fewer flare-ups.

BREZTRI is not used to relieve sudden breathing problems and will not replace a rescue inhaler. BREZTRI is not for the treatment of asthma.